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IT Source: AIFA (Italian Medicines Agency)

Medicine shortages in Italy

As of 31 Oct 2026, 2,025 products have a reported shortage in Italy, across 581 active ingredients.

Scope: All shortages reported by marketing-authorisation holders, including medicines being withdrawn. Official list.

Products short2,025today
Medicines581active ingredients
New in 30 days163reported start
Typical duration8 monthsmedian so far
No return date79%of products
Shared391medicines short elsewhere too

When today's shortages began

194 started before Nov 2024
050100150200Nov: 18Dec: 45Jan ’25: 24Jan ’25Feb: 22Mar: 18Apr: 19AprMay: 16Jun: 19Jul: 45JulAug: 19Sep: 34Oct: 44OctNov: 36Dec: 46Jan ’26: 32Jan ’26Feb: 63Mar: 87Apr: 109AprMay: 71Jun: 103Jul: 120JulAug: 129Sep: 140Oct: 163Oct

Current shortages by the month they were reported to start. A tall recent bar means a new wave.

How long they have lasted

0125250375500< 1 mo: 130130< 1 mo1–3 mo: 2882881–3 mo3–6 mo: 3023023–6 mo6–12 mo: 3793796–12 mo1–2 yrs: 3233231–2 yrs2+ yrs: 3633632+ yrs

When products are expected back

050100150200Oct: 8Nov: 63NovDec: 150Jan ’27: 27Jan ’27Feb: 28Mar: 60MarApr: 14May: 8MayJun: 33Jul: 1JulAug: 1Sep: 12Sep

1,604 products have no return date.

Why medicines are short

Manufacturing problem1,193Increased demand672Commercial decision or withdrawal106Regulatory or licensing41Distribution or logistics13

Which therapeutic classes

Nervous system470Cardiovascular system341Cancer and immune system248Anti-infectives186Digestive tract and metabolism157Blood149Musculoskeletal system108Genito-urinary system and sex hormones93Various79Sensory organs51Respiratory system48Systemic hormones48Dermatologicals42Antiparasitics5

Companies with the most products short

Zentiva250Viatris247Accord158Sandoz97Teva93Stada85Aurobindo79Sun Pharma59Towa56Doc Generici50

Grouped by company family where names clearly match. Many shortages hit generics makers because they supply most packs.

All 581 medicines short in Italy

MedicineProductsEarliest startLatest expected backMain reasonCountries
Abiraterone120 Mar 2025not givenIncreased demand
Acarbose117 Aug 2026not givenManufacturing problem
Aceclofenac231 Mar 2026not givenIncreased demand
Acetylcarnitine19 Sep 20269 Nov 2026Manufacturing problem
Acetylcysteine229 Jul 2026not givenIncreased demand
Acetylcysteine17 Sep 2026not givenManufacturing problem
Acetylsalicylic Acid131 Jan 2024not givenManufacturing problem
Acetylsalicylic Acid17 Sep 2022not givenManufacturing problem
Acetylsalicylic Acid, Combinations excl. Psycholeptics230 Apr 2026not givenManufacturing problem
Aciclovir625 Oct 202530 Jun 2027Manufacturing problem
Aciclovir125 Oct 2025not givenCommercial decision or withdrawal
Adalimumab46 Aug 2026not givenIncreased demand
Adenosine223 Dec 2025not givenDistribution or logistics
Albendazole119 Mar 2026not givenDistribution or logistics
Albumin121 Apr 202131 Dec 2026Increased demand
Alendronic Acid314 Nov 2025not givenManufacturing problem
Alendronic Acid and Colecalciferol210 Nov 2025not givenManufacturing problem
Alfacalcidol17 Aug 2026not givenIncreased demand
Alfentanil113 Sep 2024not givenIncreased demand
Alfuzosin115 Jul 2022not givenManufacturing problem
Alglucosidase Alfa130 Jul 2026not givenManufacturing problem
Alirocumab34 Oct 202631 Dec 2026Manufacturing problem
Aliskiren231 Jul 2023not givenManufacturing problem
Allopurinol410 Mar 2026not givenIncreased demand
Almotriptan316 Jun 2025not givenManufacturing problem
Alprazolam410 Sep 202530 Jun 2027Manufacturing problem
Ambrisentan21 Sep 2026not givenManufacturing problem
Ambroxol130 Apr 2025not givenManufacturing problem
Amifampridine123 Nov 2026not givenManufacturing problem
Amikacin41 Jan 202428 Feb 2027Manufacturing problem
Amino Acids323 Dec 2025not givenManufacturing problem
Amiodarone310 Dec 202530 Nov 2026Manufacturing problem
Amisulpride431 Aug 2026not givenManufacturing problem
Amlodipine916 Jun 202331 Mar 2027Manufacturing problem
Amorolfine124 Jul 2026not givenManufacturing problem
Amoxicillin and Beta-Lactamase Inhibitor911 Mar 202231 Mar 2027Increased demand
Anastrozole531 May 202331 Jan 2027Increased demand
Antithrombin III41 Jun 202531 Dec 2026Manufacturing problem
Apraclonidine11 Jun 2026not givenIncreased demand
Apremilast35 Jun 2026not givenManufacturing problem
Aprepitant415 Jan 202431 Mar 2027Manufacturing problem
Aripiprazole815 Jun 202228 Feb 2027Manufacturing problem
Artificial Tears and Other Indifferent Preparations210 Feb 202615 May 2027Increased demand
Atenolol48 Apr 202615 Dec 2026Increased demand
Atorvastatin1215 Jun 202430 Apr 2027Manufacturing problem
Atorvastatin and Ezetimibe230 Sep 202431 Mar 2027Manufacturing problem
Atosiban416 Jul 202130 Apr 2027Manufacturing problem
Atracurium125 Oct 2025not givenManufacturing problem
Avalglucosidase Alfa123 Jun 2026not givenManufacturing problem
Axitinib19 Feb 2026not givenIncreased demand
Azacitidine23 Jan 202518 Nov 2026Regulatory or licensing
Azithromycin130 Apr 2026not givenCommercial decision or withdrawal
Aztreonam and Beta-lactamase Inhibitor112 Mar 2026not givenIncreased demand
Balsalazide11 Oct 202531 Dec 2026Regulatory or licensing
Basiliximab11 Apr 2024not givenManufacturing problem
Bempedoic Acid127 Nov 202618 Dec 2026Manufacturing problem
Bempedoic Acid and Ezetimibe116 Nov 202627 Nov 2026Manufacturing problem
Bendamustine320 Feb 2026not givenIncreased demand
Benzathine Benzylpenicillin130 Apr 2024not givenManufacturing problem
Betahistine18 Sep 2024not givenManufacturing problem
Betamethasone428 Feb 2025not givenManufacturing problem
Betamethasone38 Dec 2025not givenManufacturing problem
Betamethasone and Antibiotics121 Jul 2025not givenManufacturing problem
Betamethasone and Antiinfectives24 Sep 202631 Dec 2026Manufacturing problem
Bevacizumab38 Feb 2026not givenIncreased demand
Bicalutamide41 Oct 2025not givenIncreased demand
Bifonazole113 Feb 2026not givenManufacturing problem
Bilastine37 Jul 2025not givenManufacturing problem
Bilastine119 Apr 2026not givenManufacturing problem
Binimetinib19 Nov 202623 Nov 2026Manufacturing problem
Bisoprolol911 Nov 202431 Dec 2026Increased demand
Bisoprolol and Thiazides420 Jan 2026not givenManufacturing problem
Bortezomib310 Jul 2025not givenIncreased demand
Bosentan531 May 2022not givenManufacturing problem
Bosutinib214 Feb 2025not givenIncreased demand
Botulinum Toxin115 Dec 2025not givenCommercial decision or withdrawal
Brimonidine120 Nov 2024not givenManufacturing problem
Brinzolamide115 Oct 2026not givenManufacturing problem
Bromazepam312 Dec 2022not givenManufacturing problem
Bromelains115 Sep 202631 Jan 2027Manufacturing problem
Bupivacaine36 Jan 202530 Nov 2026Commercial decision or withdrawal
Buprenorphine15 May 2026not givenRegulatory or licensing
Buprenorphine221 Feb 2022not givenIncreased demand
Bupropion27 Oct 2024not givenManufacturing problem
Butylscopolamine14 Jun 2026not givenCommercial decision or withdrawal
Cabergoline314 Oct 2025not givenManufacturing problem
Calcitonin (Salmon Synthetic)225 Oct 2025not givenManufacturing problem
Calcitriol619 Apr 2024not givenManufacturing problem
Calcium Acetate and Magnesium Carbonate124 Mar 2025not givenManufacturing problem
Calcium Folinate115 Jul 2026not givenManufacturing problem
Calcium Gluconate113 Jul 202631 Dec 2026Increased demand
Candesartan431 May 202331 Dec 2026Manufacturing problem
Candesartan and Diuretics412 Dec 2022not givenManufacturing problem
Capecitabine226 May 2023not givenManufacturing problem
Carbamazepine516 Oct 2023not givenManufacturing problem
Carbohydrates424 Jul 202331 Dec 2026Manufacturing problem
Carboplatin1120 Mar 202431 Mar 2027Manufacturing problem
Carvedilol331 Mar 2026not givenManufacturing problem
Caspofungin31 Sep 2025not givenManufacturing problem
Cefaclor11 Apr 2023not givenIncreased demand
Cefepime and Beta-Lactamase Inhibitor17 Aug 202631 Jan 2027Distribution or logistics
Cefixime17 Oct 2026not givenIncreased demand
Cefotaxime424 Aug 202531 Jan 2027Commercial decision or withdrawal
Ceftazidime518 Sep 2023not givenCommercial decision or withdrawal
Ceftriaxone128 Dec 2026not givenCommercial decision or withdrawal
Celecoxib27 Sep 2026not givenManufacturing problem
Cetirizine314 Aug 202631 Jan 2027Increased demand
Cetrorelix120 May 2025not givenManufacturing problem
Cetylpyridinium114 Nov 20269 Dec 2026Increased demand
Chloramphenicol128 Mar 2023not givenManufacturing problem
Chlorhexidine115 Jan 202631 Dec 2026Increased demand
Chlorhexidine, Combinations31 Feb 202631 Dec 2026Increased demand
Chorionic Gonadotrophin226 Mar 202631 Dec 2026Manufacturing problem
Ciclosporin128 Sep 202630 Jan 2027Manufacturing problem
Ciclosporin230 Jul 202531 Mar 2027Manufacturing problem
Cilostazol114 Sep 2026not givenManufacturing problem
Cinacalcet35 Sep 2026not givenManufacturing problem
Ciprofloxacin524 Apr 202631 Dec 2026Manufacturing problem
Ciprofloxacin11 Apr 2026not givenManufacturing problem
Ciprofloxacin130 Nov 202618 Dec 2026Increased demand
Cisatracurium517 Jun 2024not givenManufacturing problem
Citalopram631 Jan 2023not givenManufacturing problem
Citicoline31 Feb 202615 Dec 2026Manufacturing problem
Clarithromycin915 Mar 202231 Dec 2027Manufacturing problem
Clindamycin16 Sep 202630 Nov 2026Increased demand
Clindamycin, Combinations116 Nov 2026not givenManufacturing problem
Clobetasone216 Feb 2023not givenManufacturing problem
Clodronic Acid221 Aug 2023not givenCommercial decision or withdrawal
Clopidogrel310 Feb 202528 Feb 2027Manufacturing problem
Clotrimazole110 Nov 2026not givenIncreased demand
Clozapine620 Apr 2022not givenManufacturing problem
Coagulation Factor IX, II, VII and X in Combination227 Apr 202631 Dec 2026Increased demand
Coagulation Factor VIII116 Feb 2026not givenManufacturing problem
Colecalciferol1017 Oct 202218 Apr 2027Manufacturing problem
Colistin330 Apr 2025not givenManufacturing problem
Combinations11 Apr 2025not givenManufacturing problem
Combinations115 Jun 2026not givenManufacturing problem
Combinations Of Different Antibiotics15 Nov 2024not givenManufacturing problem
Conjugated Estrogens and Bazedoxifene131 Mar 2026not givenCommercial decision or withdrawal
Cromoglicic Acid, Combinations11 Sep 2024not givenManufacturing problem
Cyclophosphamide323 Dec 2025not givenIncreased demand
Cytarabine21 Oct 2026not givenCommercial decision or withdrawal
Dabigatran Etexilate92 Jan 202628 Feb 2027Manufacturing problem
Dalbavancin19 Oct 2026not givenIncreased demand
Dantrolene11 Jan 202531 Dec 2027Distribution or logistics
Dapiprazole111 Jun 2026not givenManufacturing problem
Dapoxetine415 Jul 202630 Nov 2026Manufacturing problem
Daptomycin131 May 2026not givenIncreased demand
Dasatinib113 Nov 2023not givenManufacturing problem
Deferasirox521 Dec 2022not givenManufacturing problem
Deferoxamine115 Sep 2023not givenManufacturing problem
Deflazacort230 Jun 2026not givenIncreased demand
Denosumab79 Jun 2026not givenIncreased demand
Desflurane125 Aug 2025not givenManufacturing problem
Desloratadine531 Jan 202531 Mar 2027Manufacturing problem
Desmopressin231 Oct 2024not givenIncreased demand
Dexamethasone71 Apr 202531 Jan 2027Commercial decision or withdrawal
Dexamethasone120 Oct 2025not givenManufacturing problem
Dexamethasone and Antiinfectives125 Jan 20279 Mar 2027Manufacturing problem
Dexamethasone and Antiinfectives216 Mar 202631 Dec 2026Increased demand
Dexketoprofen11 Jul 202631 Mar 2027Manufacturing problem
Dexmedetomidine127 Sep 202630 Apr 2027Manufacturing problem
Dextromethorphan17 Apr 2025not givenRegulatory or licensing
Diatrizoic Acid118 Feb 2026not givenManufacturing problem
Diazepam431 Aug 2025not givenIncreased demand
Diclofenac37 May 2025not givenManufacturing problem
Diclofenac111 Oct 202530 Jun 2027Increased demand
Diltiazem629 Feb 2024not givenManufacturing problem
Dimethyl Fumarate42 Mar 2026not givenManufacturing problem
Dinoprostone26 Oct 202530 Dec 2026Manufacturing problem
Diosmin325 Feb 2023not givenManufacturing problem
Diosmin, Combinations315 Dec 2025not givenManufacturing problem
Diphtheria-Pertussis-Poliomyelitis-Tetanus110 Jul 2025not givenIncreased demand
Dobutamine130 Nov 2024not givenDistribution or logistics
Docetaxel43 Oct 2025not givenManufacturing problem
Domperidone117 Nov 2025not givenManufacturing problem
Donepezil819 Oct 202315 Nov 2026Manufacturing problem
Dorzolamide131 Dec 2026not givenCommercial decision or withdrawal
Doxazosin430 Aug 202530 Jun 2027Manufacturing problem
Doxorubicin1031 Aug 2023not givenManufacturing problem
Dronedarone210 Sep 2025not givenIncreased demand
Drospirenone and Estrogen222 Oct 20269 Dec 2026Increased demand
Drospirenone and Ethinylestradiol121 Aug 2023not givenManufacturing problem
Duloxetine1530 Sep 202431 Dec 2026Manufacturing problem
Dutasteride330 Jun 202330 Jun 2027Manufacturing problem
Ebastine15 May 2026not givenManufacturing problem
Econazole323 Dec 20241 Jan 2027Increased demand
Econazole11 Sep 2024not givenManufacturing problem
Electrolytes1920 May 202231 Mar 2027Increased demand
Electrolytes with Carbohydrates222 Dec 2026not givenCommercial decision or withdrawal
Eletriptan416 Jul 2026not givenManufacturing problem
Eltrombopag61 Jul 202628 Feb 2027Manufacturing problem
Emtricitabine, Tenofovir Disoproxil and Efavirenz25 Aug 2022not givenManufacturing problem
Enalapril612 Feb 2024not givenManufacturing problem
Enalapril and Diuretics415 Aug 2026not givenManufacturing problem
Enalapril and lercanidipine530 Jun 2025not givenIncreased demand
Entecavir38 Aug 2022not givenIncreased demand
Epinephrine11 Aug 2026not givenIncreased demand
Epirubicin65 Jun 2026not givenManufacturing problem
Eplerenone324 Mar 2026not givenIncreased demand
Eribulin130 Jun 2026not givenIncreased demand
Erlotinib11 Jan 2027not givenManufacturing problem
Ertapenem118 Jul 2025not givenManufacturing problem
Erythromycin131 Jan 2025not givenManufacturing problem
Erythromycin222 Dec 2026not givenManufacturing problem
Erythropoietin334 Jun 202430 Jun 2027Increased demand
Escitalopram930 Dec 202230 Jun 2027Manufacturing problem
Eslicarbazepine16 Jul 2026not givenIncreased demand
Esmolol212 Aug 202430 Sep 2027Manufacturing problem
Esomeprazole1415 May 2025not givenManufacturing problem
Estazolam110 Oct 202630 Nov 2026Manufacturing problem
Estradiol31 Sep 202631 Mar 2027Increased demand
Etanercept125 Sep 202630 Nov 2026Increased demand
Etoposide430 Jun 2026not givenIncreased demand
Etoricoxib1124 Dec 202130 Jun 2027Manufacturing problem
Etranacogene Dezaparvovec19 Mar 202631 Dec 2026Manufacturing problem
Exemestane35 Aug 2026not givenIncreased demand
Ezetimibe31 Jul 2025not givenCommercial decision or withdrawal
Fat Emulsions312 Dec 2024not givenManufacturing problem
Febuxostat417 Feb 202530 Nov 2026Manufacturing problem
Felodipine21 Oct 2022not givenManufacturing problem
Fenofibrate117 Jan 2022not givenManufacturing problem
Fentanyl1817 Jul 202315 May 2027Manufacturing problem
Fentanyl119 Feb 202431 Dec 2027Manufacturing problem
Ferrous Sulfate15 Aug 202612 Nov 2026Increased demand
Fexofenadine217 Jan 2023not givenIncreased demand
Fibrinogen, Human23 Nov 20251 Mar 2027Manufacturing problem
Filgrastim430 Jul 202621 Mar 2027Manufacturing problem
Finasteride815 Oct 202531 Dec 2026Manufacturing problem
Finasteride420 Mar 202431 Jan 2027Manufacturing problem
Fingolimod25 Jun 2026not givenManufacturing problem
Flecainide312 Aug 202630 Nov 2026Increased demand
Fluconazole831 Oct 2024not givenCommercial decision or withdrawal
Flumazenil131 May 2026not givenManufacturing problem
Fluocinolone Acetonide and Antibiotics115 Jun 20251 Nov 2026Manufacturing problem
Fluocinolone Acetonide and Antiinfectives115 Jan 20279 Mar 2027Manufacturing problem
Fluorouracil39 May 2023not givenManufacturing problem
Fluoxetine75 Feb 202430 Nov 2026Manufacturing problem
Flurbiprofen11 Apr 202610 Oct 2027Commercial decision or withdrawal
Flutamide11 Mar 2022not givenManufacturing problem
Flutemetamol (18F)130 Nov 202613 Jan 2027Manufacturing problem
Follitropin Alfa227 Oct 2026not givenManufacturing problem
Formoterol and Beclometasone315 Apr 2026not givenIncreased demand
Foscarnet21 Mar 202531 Jan 2027Manufacturing problem
Fosfomycin11 Feb 2026not givenIncreased demand
Fosinopril119 Aug 2024not givenIncreased demand
Fosinopril and Diuretics123 Aug 2024not givenIncreased demand
Fostamatinib122 Jun 2026not givenManufacturing problem
Frovatriptan11 Oct 2026not givenManufacturing problem
Fulvestrant330 Aug 2025not givenCommercial decision or withdrawal
Furosemide610 Oct 2025not givenManufacturing problem
Fusidic Acid120 Nov 2025not givenManufacturing problem
Gabapentin822 Aug 202230 Jun 2027Manufacturing problem
Gadobutrol12 Dec 20261 Feb 2027Manufacturing problem
Gadopiclenol230 Jan 20269 Sep 2027Increased demand
Gadoteric Acid84 Apr 202313 Dec 2027Increased demand
Gadoxetic Acid128 Jul 202630 Nov 2026Manufacturing problem
Galantamine130 May 2026not givenIncreased demand
Gefitinib120 Mar 2026not givenRegulatory or licensing
Gelatin Agents24 Mar 2026not givenIncreased demand
Gemcitabine85 Jan 202431 Oct 2026Manufacturing problem
Gemfibrozil27 Jul 2026not givenManufacturing problem
Gentamicin230 Nov 2024not givenCommercial decision or withdrawal
Gliclazide11 Jan 2026not givenManufacturing problem
Glimepiride31 Feb 2026not givenIncreased demand
Glycerol128 Dec 2026not givenManufacturing problem
Glyceryl Trinitrate21 Jul 202629 Nov 2026Increased demand
Golimumab11 Dec 202620 Feb 2027Increased demand
Granisetron111 Dec 2025not givenManufacturing problem
Haloperidol114 Oct 202630 Nov 2026Manufacturing problem
Heparin231 Jul 2025not givenIncreased demand
Hepatitis A, Inactivated, Whole Virus117 Aug 202616 Nov 2026Increased demand
Hepatitis B Immunoglobulin420 Mar 2026not givenIncreased demand
Hepatitis B, Purified Antigen127 Aug 2026not givenIncreased demand
Hydroxycarbamide111 Nov 2025not givenIncreased demand
Ibandronic Acid530 Nov 2022not givenManufacturing problem
Ibopamine11 Jun 2023not givenManufacturing problem
Ibritumomab Tiuxetan (90Y)11 Jun 2020not givenManufacturing problem
Ibuprofen129 May 202231 Mar 2027Manufacturing problem
Icatibant324 Mar 202615 Feb 2027Increased demand
Idarubicin120 Oct 2026not givenManufacturing problem
Ifosfamide116 Dec 202531 Mar 2027Increased demand
Iloprost316 Sep 2024not givenManufacturing problem
Imatinib231 Aug 2026not givenManufacturing problem
Immunoglobulins, Normal Human, for Extravascular Adm.1416 Jun 202131 Dec 2026Increased demand
Immunoglobulins, Normal Human, for Intravascular Adm.1710 Apr 20191 Mar 2027Increased demand
Influenza, Inactivated, Split Virus Or Surface Antigen27 Aug 2026not givenManufacturing problem
Influenza, Live Attenuated27 Sep 202631 Mar 2027Manufacturing problem
Insulin Glargine18 Oct 202616 Nov 2026Manufacturing problem
Iobitridol712 Apr 202327 Dec 2027Increased demand
Iodixanol125 Aug 2026not givenManufacturing problem
Iohexol110 Sep 2026not givenManufacturing problem
Iomeprol1229 Oct 2024not givenIncreased demand
Iopamidol79 Dec 202431 Dec 2026Increased demand
Ioversol328 Apr 202323 Sep 2027Increased demand
Irbesartan224 Apr 2026not givenIncreased demand
Irbesartan and Diuretics626 Sep 2022not givenManufacturing problem
Irinotecan420 May 2025not givenManufacturing problem
Isosorbide Mononitrate331 Dec 202331 Oct 2026Commercial decision or withdrawal
Itraconazole31 Sep 202631 Dec 2026Manufacturing problem
Ivabradine731 Mar 202513 Nov 2026Manufacturing problem
Ivacaftor16 Oct 2026not givenManufacturing problem
Ivacaftor and Lumacaftor16 Oct 2026not givenManufacturing problem
Ketazolam215 Jul 2026not givenRegulatory or licensing
Ketoprofen129 Nov 2023not givenManufacturing problem
Ketoprofen81 Feb 20221 Jan 2028Manufacturing problem
Lacidipine57 Jul 202631 Oct 2026Increased demand
Lacosamide157 Aug 2023not givenIncreased demand
Lactulose227 Mar 2023not givenIncreased demand
Lamivudine311 Sep 2025not givenIncreased demand
Lamivudine and Abacavir128 Jul 2025not givenManufacturing problem
Lamotrigine11 Jul 2026not givenIncreased demand
Lanreotide328 Sep 202331 Mar 2027Manufacturing problem
Lansoprazole520 May 2025not givenManufacturing problem
Lapatinib115 Nov 2026not givenManufacturing problem
Latanoprost330 Nov 202231 Dec 2026Manufacturing problem
Leflunomide127 Oct 2023not givenManufacturing problem
Lenalidomide1911 Jul 202429 Mar 2027Increased demand
Lercanidipine223 Feb 202631 Mar 2027Manufacturing problem
Letrozole119 Oct 2026not givenIncreased demand
Leuprorelin26 Feb 2026not givenManufacturing problem
Levetiracetam1930 May 202330 Jun 2027Increased demand
Levobupivacaine211 Dec 202531 Dec 2026Manufacturing problem
Levocarnitine31 Feb 2023not givenManufacturing problem
Levocetirizine122 Nov 2026not givenManufacturing problem
Levodopa, Decarboxylase Inhibitor and COMT Inhibitor21 Jan 2027not givenManufacturing problem
Levofloxacin130 Sep 2024not givenIncreased demand
Levofloxacin11 Dec 2025not givenCommercial decision or withdrawal
Levonorgestrel and Ethinylestradiol130 Nov 2025not givenManufacturing problem
Levosimendan125 Jun 2025not givenManufacturing problem
Levosulpiride130 Apr 2025not givenManufacturing problem
Levothyroxine Sodium517 Sep 202531 Dec 2026Manufacturing problem
Lidocaine511 Apr 2025not givenCommercial decision or withdrawal
Linezolid219 Nov 202631 Jan 2027Manufacturing problem
Liothyronine Sodium217 Sep 202531 Dec 2026Manufacturing problem
Lisinopril121 Dec 2026not givenManufacturing problem
Lisinopril and Diuretics131 Aug 2026not givenRegulatory or licensing
Loperamide15 Aug 2026not givenManufacturing problem
Lopinavir and Ritonavir11 Apr 2026not givenManufacturing problem
Lorazepam430 Apr 202530 Jun 2027Manufacturing problem
Lormetazepam114 Nov 2022not givenManufacturing problem
Losartan31 Dec 202531 Dec 2026Commercial decision or withdrawal
Losartan and Diuretics21 Sep 2021not givenManufacturing problem
Loteprednol25 Dec 202631 Dec 2026Manufacturing problem
Lurasidone230 Oct 2026not givenManufacturing problem
Macrogol, Combinations617 Nov 202530 Mar 2027Regulatory or licensing
Magaldrate221 Oct 2022not givenIncreased demand
Manidipine121 Mar 2022not givenManufacturing problem
Mannitol21 Nov 202430 Nov 2026Manufacturing problem
Measles, Combinations with Mumps and Rubella, Live Attenuated124 Jul 2026not givenIncreased demand
Measles, Combinations with Mumps, Rubella and Varicella, Live Attenuated21 Jan 201931 Dec 2026Manufacturing problem
Mefloquine110 Aug 202615 Dec 2026Increased demand
Megestrol15 Dec 2024not givenIncreased demand
Melatonin129 May 2026not givenIncreased demand
Meloxicam115 Jan 2025not givenCommercial decision or withdrawal
Melphalan19 Sep 2022not givenIncreased demand
Memantine64 Dec 202429 Dec 2026Manufacturing problem
Meningococcus A,C,Y,W-135, Tetravalent Purified Polysaccharides Antigen Conjugated128 Sep 2026not givenIncreased demand
Mepolizumab125 Nov 202618 Dec 2026Manufacturing problem
Meropenem320 Feb 2026not givenManufacturing problem
Mesna124 Dec 2025not givenManufacturing problem
Metformin1720 Aug 2024not givenManufacturing problem
Metformin and Canagliflozin121 Sep 2026not givenIncreased demand
Metformin and Pioglitazone127 Mar 2026not givenManufacturing problem
Metformin and Sitagliptin114 Jul 202631 Dec 2026Manufacturing problem
Metformin and Sulfonylureas11 Jun 202530 Nov 2027Commercial decision or withdrawal
Metformin and Vildagliptin215 Dec 2023not givenManufacturing problem
Methotrexate231 Aug 202631 Oct 2026Manufacturing problem
Methylergometrine11 Oct 2026not givenManufacturing problem
Methylnaltrexone Bromide116 Aug 2024not givenManufacturing problem
Methylprednisolone525 Nov 2024not givenManufacturing problem
Methylthioninium Chloride21 Aug 20251 May 2027Increased demand
Metoprolol131 Aug 2026not givenIncreased demand
Metronidazole114 Sep 2026not givenManufacturing problem
Metronidazole119 Mar 2026not givenManufacturing problem
Miconazole131 Jan 2023not givenManufacturing problem
Midazolam330 Jun 202431 Dec 2026Increased demand
Miglustat228 Feb 2022not givenManufacturing problem
Mirtazapine230 Nov 2022not givenManufacturing problem
Mivacurium Chloride21 Nov 202531 May 2027Manufacturing problem
Mometasone415 Aug 2024not givenManufacturing problem
Montelukast41 May 2024not givenManufacturing problem
Moxifloxacin315 Jan 202630 Apr 2027Manufacturing problem
Multienzymes (Lipase, Protease etc.)31 Jan 202231 Dec 2026Increased demand
Mycophenolic Acid324 Apr 202631 Jan 2027Manufacturing problem
Nabumetone21 Dec 2025not givenCommercial decision or withdrawal
Nadolol123 Jun 202630 Apr 2027Manufacturing problem
Naloxone117 Apr 2024not givenManufacturing problem
Naltrexone118 May 2026not givenIncreased demand
Naphazoline22 Dec 202230 Jun 2027Manufacturing problem
Naproxen119 Mar 2026not givenManufacturing problem
Nebivolol21 Mar 202631 Mar 2027Manufacturing problem
Nebivolol and Thiazides23 Aug 202631 Mar 2027Manufacturing problem
Netilmicin126 Jun 2026not givenCommercial decision or withdrawal
Nifedipine725 Oct 2025not givenManufacturing problem
Nimesulide119 Feb 202619 Feb 2027Manufacturing problem
Nintedanib426 Aug 2026not givenIncreased demand
Nivolumab113 Mar 20269 Nov 2026Manufacturing problem
Nortriptyline21 Sep 20251 Sep 2027Manufacturing problem
Octreotide414 Jul 2025not givenManufacturing problem
Olanzapine1615 Jul 202230 Jun 2027Manufacturing problem
Olipudase Alfa110 Jul 2026not givenManufacturing problem
Olmesartan Medoxomil1330 Jul 202230 Jun 2027Manufacturing problem
Olmesartan Medoxomil and Amlodipine621 Aug 202330 Nov 2026Manufacturing problem
Olmesartan Medoxomil and Diuretics1131 Aug 2023not givenManufacturing problem
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide811 Oct 202410 Dec 2026Increased demand
Omalizumab28 Dec 2026not givenIncreased demand
Omega-3-Triglycerides Incl. Other Esters and Acids113 Apr 2026not givenIncreased demand
Omeprazole1331 Jan 2023not givenCommercial decision or withdrawal
Ondansetron71 Dec 202531 Dec 2026Increased demand
Oritavancin15 Aug 2026not givenIncreased demand
Oxaliplatin624 Feb 2025not givenManufacturing problem
Oxcarbazepine223 Jul 2025not givenManufacturing problem
Oxitriptan18 Jul 2026not givenManufacturing problem
Oxybuprocaine216 Nov 20261 Feb 2027Manufacturing problem
Oxybutynin11 Jul 2026not givenManufacturing problem
Oxycodone121 Dec 2026not givenManufacturing problem
Oxytocin129 Jul 2026not givenIncreased demand
Paclitaxel830 May 202230 Nov 2026Manufacturing problem
Paliperidone1428 Jun 202431 Dec 2026Increased demand
Palonosetron210 Dec 2024not givenManufacturing problem
Pantoprazole75 Apr 2024not givenIncreased demand
Paracetamol1213 Mar 202330 Jun 2027Manufacturing problem
Paracetamol, Combinations excl. Psycholeptics224 Jan 2023not givenCommercial decision or withdrawal
Paracetamol, Combinations with Psycholeptics18 Aug 2025not givenCommercial decision or withdrawal
Paricalcitol214 Sep 202631 May 2027Regulatory or licensing
Paroxetine724 Oct 202230 Apr 2027Manufacturing problem
Pazopanib330 May 2026not givenIncreased demand
Pemetrexed220 Jul 2022not givenIncreased demand
Pentostatin116 Sep 2026not givenManufacturing problem
Pentoxifylline115 Aug 20261 Jan 2027Regulatory or licensing
Perindopril51 Jun 202631 Jan 2027Manufacturing problem
Perindopril and Amlodipine73 Jul 202530 Nov 2027Manufacturing problem
Perindopril and Diuretics631 Jul 202611 Dec 2026Increased demand
Pertussis, Purified Antigen, Combinations with Toxoids119 Jan 2026not givenIncreased demand
Pilocarpine11 Oct 202630 Jun 2027Manufacturing problem
Pioglitazone51 Jun 202615 Dec 2026Manufacturing problem
Piperacillin and Beta-Lactamase Inhibitor51 Nov 202431 Oct 2026Increased demand
Pirfenidone915 Feb 20246 Nov 2026Manufacturing problem
Pneumococcus, Purified Polysaccharides Antigen11 Jun 2026not givenIncreased demand
Polystyrene Sulfonate122 Sep 2025not givenManufacturing problem
Pomalidomide719 Dec 2024not givenManufacturing problem
Posaconazole131 Jan 2024not givenManufacturing problem
Potassium Canrenoate11 Oct 202526 Feb 2027Manufacturing problem
Povidone-Iodine41 Sep 202531 Dec 2026Manufacturing problem
Povidone-Iodine122 Dec 20261 Feb 2027Manufacturing problem
Pralidoxime214 Mar 2024not givenManufacturing problem
Pramipexole1030 Jun 202231 Jan 2027Manufacturing problem
Prasugrel119 Apr 2024not givenManufacturing problem
Pravastatin628 Feb 2026not givenManufacturing problem
Prazepam11 Jul 2022not givenManufacturing problem
Prednisone11 Nov 202631 Mar 2027Manufacturing problem
Pregabalin251 May 202130 Jun 2027Manufacturing problem
Progesterone114 May 202631 Dec 2026Increased demand
Progesterone and Estrogen27 Feb 2026not givenIncreased demand
Proguanil and Atovaquone217 Mar 2026not givenIncreased demand
Propafenone224 Apr 2026not givenIncreased demand
Propofol627 Dec 202430 Apr 2027Manufacturing problem
Propranolol123 Oct 2024not givenManufacturing problem
Quetiapine556 Jul 202130 Jun 2027Manufacturing problem
Rabeprazole31 Apr 2024not givenManufacturing problem
Rabies, Inactivated, Whole Virus126 Oct 2026not givenIncreased demand
Raltitrexed119 Jan 2027not givenManufacturing problem
Ramipril230 Apr 2026not givenIncreased demand
Ramipril and Amlodipine631 Dec 2023not givenManufacturing problem
Ramipril and Diuretics61 Jan 202530 Jun 2027Manufacturing problem
Ranolazine31 Apr 202430 Nov 2026Increased demand
Rasagiline217 May 202630 Nov 2026Manufacturing problem
Repaglinide230 Jun 202631 Dec 2026Manufacturing problem
Respiratory Syncytial Virus Vaccines11 Oct 2026not givenCommercial decision or withdrawal
Rifabutin130 Oct 2025not givenManufacturing problem
Rifampicin15 Aug 2021not givenManufacturing problem
Rifampicin and Isoniazid116 Aug 202131 Dec 2026Manufacturing problem
Riluzole231 Dec 2022not givenIncreased demand
Risdiplam123 Sep 202630 Nov 2026Manufacturing problem
Risedronic Acid714 Feb 2025not givenIncreased demand
Risperidone79 Dec 2024not givenManufacturing problem
Ritonavir216 Feb 2026not givenManufacturing problem
Rituximab526 Nov 2025not givenIncreased demand
Rivaroxaban627 Dec 202431 Dec 2026Increased demand
Rivastigmine1015 Oct 2021not givenManufacturing problem
Rizatriptan416 Jun 2025not givenManufacturing problem
Rocuronium Bromide18 May 2026not givenIncreased demand
Ropinirole81 Oct 2024not givenManufacturing problem
Ropivacaine34 Dec 202531 Dec 2026Manufacturing problem
Rosuvastatin830 Apr 202331 Mar 2027Manufacturing problem
Rosuvastatin and Amlodipine431 May 2024not givenManufacturing problem
Rosuvastatin and Ezetimibe316 Nov 2026not givenIncreased demand
Roxithromycin231 Aug 202631 Dec 2026Regulatory or licensing
Rupatadine231 Jul 2026not givenIncreased demand
Salmeterol and Fluticasone58 Jun 2026not givenManufacturing problem
Samarium (153Sm) Lexidronam126 Oct 202620 Nov 2026Manufacturing problem
Selenium (75Se) Tauroselcholic Acid12 Nov 20268 Jan 2027Distribution or logistics
Sertraline145 Aug 202231 Mar 2027Manufacturing problem
Sevelamer314 Jul 2026not givenManufacturing problem
Sevoflurane12 Mar 2026not givenCommercial decision or withdrawal
Sildenafil1724 Apr 2026not givenIncreased demand
Silicones129 Nov 2023not givenManufacturing problem
Silodosin129 Mar 2024not givenManufacturing problem
Simvastatin515 Nov 202130 Jun 2027Manufacturing problem
Simvastatin and Ezetimibe1528 Feb 2021not givenManufacturing problem
Sitagliptin1012 May 202431 Dec 2026Manufacturing problem
Sodium Chloride124 Feb 2025not givenIncreased demand
Solifenacin227 Aug 2026not givenManufacturing problem
Sorafenib231 Jan 2023not givenManufacturing problem
Sucralfate11 Oct 20261 Feb 2027Manufacturing problem
Sugammadex51 Jan 2024not givenIncreased demand
Sultiame128 Oct 2026not givenManufacturing problem
Sumatriptan830 Nov 2024not givenManufacturing problem
Sunitinib1131 Oct 202231 Mar 2027Increased demand
Tacrolimus43 Nov 2025not givenManufacturing problem
Tadalafil2530 Jun 202030 Jun 2027Manufacturing problem
Tamsulosin218 Mar 202431 Dec 2026Increased demand
Tamsulosin and Solifenacin11 Oct 2026not givenManufacturing problem
Technetium (99mTc) Antigranulocyte Antibody117 Sep 202526 Jun 2028Manufacturing problem
Teicoplanin212 Jun 202431 Mar 2027Manufacturing problem
Telmisartan612 Dec 2022not givenManufacturing problem
Telmisartan and Diuretics126 Jun 2023not givenManufacturing problem
Temozolomide116 Nov 202528 Feb 2027Manufacturing problem
Tenofovir Disoproxil and Emtricitabine31 Oct 202430 Nov 2026Manufacturing problem
Terazosin230 Nov 2024not givenCommercial decision or withdrawal
Terbinafine331 Aug 2026not givenRegulatory or licensing
Teriflunomide616 Jun 202530 Nov 2026Increased demand
Terlipressin130 Apr 2024not givenManufacturing problem
Tetanus Toxoid114 Apr 2025not givenManufacturing problem
Tetanus Toxoid, Combinations with Diphtheria Toxoid115 Sep 2026not givenManufacturing problem
Tetrabenazine231 Oct 2022not givenManufacturing problem
Thiocolchicoside131 Jul 2025not givenManufacturing problem
Thiotepa215 Sep 2024not givenManufacturing problem
Tibolone110 Sep 2025not givenManufacturing problem
Ticagrelor25 Jun 2026not givenManufacturing problem
Ticlopidine11 Sep 20267 Dec 2026Manufacturing problem
Timolol226 Mar 202631 Oct 2026Increased demand
Timolol, Combinations717 Jul 20231 Jun 2027Manufacturing problem
Tobramycin512 Apr 2023not givenManufacturing problem
Tocilizumab419 Aug 2024not givenManufacturing problem
Tolvaptan229 Jun 2026not givenManufacturing problem
Topiramate1028 Jul 2025not givenManufacturing problem
Topotecan128 Jul 202630 Sep 2028Manufacturing problem
Trabectedin21 Jan 2026not givenManufacturing problem
Tramadol215 Dec 2025not givenManufacturing problem
Tranexamic Acid128 Jan 2025not givenIncreased demand
Travoprost315 Dec 2023not givenManufacturing problem
Trazodone215 Mar 202630 Jun 2027Manufacturing problem
Triamcinolone314 Nov 2019not givenManufacturing problem
Trimipramine114 May 20268 Dec 2026Regulatory or licensing
Triptorelin18 Feb 202131 Dec 2027Manufacturing problem
Umeclidinium Bromide120 Oct 2026not givenManufacturing problem
Urapidil11 Aug 2026not givenManufacturing problem
Urofollitropin224 Apr 202631 Dec 2026Manufacturing problem
Ursodeoxycholic Acid25 Aug 2024not givenManufacturing problem
Ustekinumab31 Oct 2025not givenIncreased demand
Valaciclovir327 Jul 2026not givenIncreased demand
Valganciclovir118 Sep 2026not givenIncreased demand
Valproic Acid626 Jun 202531 Mar 2027Manufacturing problem
Valsartan93 Jul 201831 Mar 2027Manufacturing problem
Valsartan and Amlodipine231 May 2024not givenManufacturing problem
Valsartan and Diuretics1414 Jul 202530 Jun 2027Manufacturing problem
Valsartan and Sacubitril120 Oct 202613 Nov 2026Increased demand
Valsartan, amlodipine and hydrochlorothiazide41 Mar 2026not givenManufacturing problem
Vancomycin313 Jul 2026not givenIncreased demand
Vardenafil11 Jan 2027not givenManufacturing problem
Varicella, Live Attenuated19 Dec 2025not givenManufacturing problem
Various231 Oct 202530 Nov 2026Manufacturing problem
Velmanase Alfa121 Oct 20264 Nov 2026Manufacturing problem
Venlafaxine1231 Jul 202328 Feb 2027Manufacturing problem
Verteporfin131 Jul 202031 Dec 2026Manufacturing problem
Vildagliptin120 Apr 2026not givenManufacturing problem
Vinblastine13 Jul 2026not givenManufacturing problem
Vindesine11 Mar 2023not givenManufacturing problem
Vinflunine11 Jan 20271 Oct 2027Manufacturing problem
Vinorelbine11 May 2026not givenCommercial decision or withdrawal
Von Willebrand Factor and Coagulation Factor Viii in Combination123 Sep 2026not givenManufacturing problem
Voriconazole627 Oct 202528 Feb 2027Increased demand
Voxelotor123 Sep 2024not givenCommercial decision or withdrawal
Xylometazoline11 Apr 2026not givenManufacturing problem
Ziprasidone114 Sep 2026not givenManufacturing problem
Zofenopril and Diuretics12 Sep 2026not givenManufacturing problem
Zoledronic Acid131 Jul 2026not givenManufacturing problem
Zolpidem228 Jan 20261 Mar 2027Manufacturing problem
Zonisamide36 Feb 202630 Nov 2026Increased demand