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ATC L01BA01 · Antineoplastic Agents

Methotrexate shortage

As of 31 Oct 2026, Methotrexate has a reported shortage in 2 of the 5 countries we track (Spain, Belgium), covering 4 products.

Countries2/5
Products4packs or presentations
Short since25 Apr 20224.5 years ago
Earliest return28 Dec 2026company estimate
No return date0products
Main reasonNot stated
GermanyNo reported shortageItalyNo reported shortageSpain2 packs shortAustriaNo reported shortageBelgium2 packs short

Timeline

SpainBelgium
20232024202520262028METOTREXATO ACCORD 25 MG/ML SOLUCION INYECTAMETOTREXATO ACCORD 25 MG/ML SOLUCION INYECTABLE EFG, 1 vial de 20 mlMETOTREXATO ACCORD 25 MG/ML SOLUCION INYECTAMETOTREXATO ACCORD 25 MG/ML SOLUCION INYECTABLE EFG, 1 vial de 40 mlEmthexate 50 mg/2 ml inj. sol. i.m./i.thec./Emthexate 50 mg/2 ml inj. sol. i.m./i.thec./i.ventricul./i.v./i.arter. vial 2 mlMethotrexate Accord Healthcare 25 mg/ml inj.Methotrexate Accord Healthcare 25 mg/ml inj. sol. i.m./i.thec./i.v./i.arter. vial 2 mltoday

Solid bars run from the reported start to today; faded bars show the time left until the expected return. An arrow means no return date was given.

Affected products

CountryProductHolderSinceExpected backReason
ESMETOTREXATO ACCORD 25 MG/ML SOLUCION INYECTABLE EFG, 1 vial de 20 mlAccord Healthcare S.L.U.25 Apr 202230 Dec 2026Not stated
ESMETOTREXATO ACCORD 25 MG/ML SOLUCION INYECTABLE EFG, 1 vial de 40 mlAccord Healthcare S.L.U.18 Jun 202630 Dec 2026Not stated
BEEmthexate 50 mg/2 ml inj. sol. i.m./i.thec./i.ventricul./i.v./i.arter. vial 2 mlTeva10 Jul 202628 Dec 2026Manufacturing problem
Delay in production
BEMethotrexate Accord Healthcare 25 mg/ml inj. sol. i.m./i.thec./i.v./i.arter. vial 2 mlAccord Healthcare3 Aug 202627 Jan 2028Increased demand

"Expected back" is the date the company gave the authority, when it gave one. Ask a pharmacist about alternatives.

Related medicines also in short supply

Pemetrexed Raltitrexed